A recent study by CBU’s Sean Bankier and his collaborators demonstrates how new methods may open the door to improving diagnostics and patient follow‑up through blood tests instead of more invasive procedures. Read the full story here in English and Norwegian You can find the study here
A new study shows that the Aire protein—best known for helping the immune system learn to tolerate the body’s own tissues—also plays an important role in producing interferons within the thymus. Using single‑cell RNA sequencing, researchers found that mice lacking Aire had weakened interferon‑driven signals in several developing thymus cell types, including maturing T cells …
In a new study published in Nature, researchers from the University of Geneva, the EMBL and CBU/UiB present the first large-scale map of the lipids processed by lipid transfer proteins (LTPs) in human cells. The study identified nearly 500 new LTP-ligands pairs, including both well-studied LTPs and those that were formerly orphaned. Nathalie Reuter and …
In the first paper, published in Colloids and Surfaces A: Physicochemical and Engineering Aspects, Markus and his team propose a method to correct inconsistencies in lipid monolayer experiments. They combine X-ray reflectometry with molecular simulations to determine accurate molecular areas. This correction improves the reliability of surface-pressure–area isotherms. It was successfully applied to several lipid …
ATP is a molecule that provides energy for many cellular processes, driving life. The variation of ATP concentration through the cell is an important influence on these processes, but this variation is hard to explore with experiments. In a new paper in Biophysical Journal, we use a simple mathematical model to explore the general circumstances …
We are please to announce that our postdoc Sean Alexander Bankier together with the co-authors published the manuscript: “Plasma cortisol-linked gene networks in hepatic and adipose tissues implicate corticosteroid-binding globulin in modulating tissue glucocorticoid action and cardiovascular risk”. Frontiers | Plasma cortisol-linked gene networks in hepatic and adipose tissues implicate corticosteroid-binding globulin in modulating tissue …
RNA molecules can form secondary and tertiary structures that can regulate their localization and function. These structures are rarely static and different copies of the same RNA can often adopt many different conformations. Despite this most methods are only capable of characterizing RNA at the consensus level, looking at the average over RNA molecules. A new …
Our group leader Markus Miettinen has his paper out with the title: Structure of POPC Lipid Bilayers in OPLS3e Force Field. Read here.
CBU group leader, Markus Miettinen, together with the co-authors published a perspective paper “Emerging Era of Biomolecular Membrane Simulations: Automated Physically-Justifed Force Field Development and Quality-Evaluated Databanks” in which they discuss the current status of all-atom simulations of biomembranes, and outline their view on how these should be further developed by harnessing large databanks and …
We are congratulating Iain George Johnston and the coauthors with the paper that has recently come out: “Symmetry and simplicity spontaneously emerge from the algorithmic nature of evolution”
