Successful PhD Defense – Unraveling the Mysteries of the Translatome.

On March 12th Håkon Tjeldnes successfully defended his PhD thesis titled: Unraveling the Mysteries of the Translatome.
Protein synthesis, also called translation, is a fundamental process in gene regulation. The translation process consists simply of molecules, called ribosomes, using RNA as a template to create proteins that the cell needs. However, it has been uncovered that translation processes are much more complex than initially assumed. To explore protein synthesis at a detailed level, the development of “Ribo-seq,” also known as Ribosome Profiling data, has been crucial. Ribo-seq is a molecular biological technique that enables the observation of ribosome activity. In his work, he has focused on current challenges in the field by proposing practical and applicable solutions. The thesis presents a collection of tools specifically developed for the analysis of Ribo-seq data. These contributions aim to fill existing gaps in the field and provide researchers with valuable resources to expand their understanding of translation processes: