CBU

2024

45. Adaptive digital tissue deconvolution.
Görtler F, Mensching-Buhr M, Skaar Ø, Schrod S, Sterr T, Schäfer A, Beißbarth T, Joshi A, Zacharias HU, Grellscheid SN, Altenbuchinger M. Bioinformatics. 2024 40(Suppl 1):i100-i109. 10.1093/bioinformatics/btae263

44. PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects.
Atkinson R, Georgiou M, Yang C, Szymanska K, Lahat A, Vasconcelos E, Ji Y, Molina M, Collin GJ, Queen R, Birthe D, Watson A, Kurzawa-Akanbi M, Laws R, Saxena A, Beh C, Siachisumo C, Göertler F, Karwatka M, Lako M. Nat Commun. 2024 15. 10.1038/s41467-024-47253-0

2023

43. FAIR+E pathogen data for surveillance and research: lessons from COVID-19.
Neves A, Cuesta I, Hjerde E, Klemetsen T, Salgado D, van Helden J, Rahman N, Fatima N, Karathanasis N, Zmora P, Åkerström WN, Grellscheid SN, Waheed Z, Blomberg N. Front Public Health. 2023 11:1289945. 10.3389/fpubh.2023.1289945

42. An integrated RNA-proteomic landscape of drug induced senescence in a cancer cell line.
Al-Roshdi M, Stevenson T, Görtler F, Grellscheid SN. F1000Research. 2023 12:1013 10.12688/f1000research.133203.1

41. Traditional Norwegian kveik yeast: an ancient sister group to domesticated Saccharomyces cerevisiae.
Dondrup M, Eiken HG, Martinussen AO, Haugland LK, Holdhus R, Dolan DWP, Grellscheid SN, Hagen S, Elameen A, Myking T. bioRxiv. 2023.07.03.547515. 10.1101/2023.07.03.547515

40. A bending rigidity parameter for stress granule condensates.
Law JO, Jones CM, Stevenson T, Williamson TA, Turner MS, Kusumaatmaja H, Grellscheid SN. Sci Adv. 2023 9(20):eadg0432. 10.1126/sciadv.adg0432

39. MERISTEM-DEFECTIVE regulates the balance between stemness and differentiation in the root meristem through RNA splicing control.
Thompson HL, Shen W, Matus R, Kakkar M, Jones C, Dolan D, Grellscheid S, Yang X, Zhang N, Mozaffari-Jovin S, Chen C, Zhang X, Topping JF, Lindsey K. Development. 2023 150(7):dev201476. 10.1242/dev.201476

38. Progressive motor and non-motor symptoms in Park7 knockout zebrafish.
Chavali LNM, Yddal I, Bifulco E, Mannsåker S, Røise D, Law JO, Frøyset A-K, Grellscheid SN, Fladmark KE. Int J Mol Sci. 2023 24(7):6456. 10.3390/ijms24076456 

37. An integrated RNA-proteomic landscape of drug induced senescence in a cancer cell line.
Stevenson T, Al-Roshdi M, Görtler F, Grellscheid SN. bioRxiv. 2023.03.21.533605. 10.1101/2023.03.21.533605

2022

36. Peptide-based coacervate-core vesicles with semipermeable membranes.
Abbas M, Law JO, Grellscheid SN, Huck WTS, Spruijt E. Adv Mater. 2022, 34, 2202913. 10.1002/adma.202202913

35. Using shape fluctuations to probe the mechanics of stress granules.
Law JO, Jones CM, Stevenson T, Turner MS, Kusumaatmaja H, Grellscheid SN.

34. Particle detection and tracking with DNA.
O’Hare CAJ, Matsos VG, Newton J, Smith K, Hochstetter J, Jaiswar R, Kyaw W, McNamara A, Kuncic Z, Grellscheid SN, Bœhm C. Eur Phys J C. 2022 82, 306. 10.1140/epjc/s10052-022-10264-6

2021

32. Deep conservation of ribosome stall sites across RNA processing genes.
Chyżyńska K, Labun K, Jones C, Grellscheid SN, Valen E. NAR Genom Bioinform. 2021 3(2):lqab038. 10.1093/nargab/lqab038

31. Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner.
Lagnado A, Leslie J, Ruchaud-Sparagano MH, Victorelli S, Hirsova P, Ogrodnik M, Collins AL, Vizioli MG, Habiballa L, Saretzki G, Evans SA, Salmonowicz H, Hruby A, Geh D, Pavelko KD, Dolan D, Reeves HL, Grellscheid SN, Wilson CH, Pandanaboyana S, Doolittle M, von Zglinicki T, Oakley F, Gallage S, Wilson CL, Birch J, Carroll B, Chapman J, Heikenwalder M, Neretti N, Khosla S, Masuda CA, Tchkonia T, Kirkland JL, Jurk D, Mann DA, Passos JF. EMBO J. 2021 40(9):e106048. 10.15252/embj.2020106048

2020

30. Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathies.
Lake AVR, Smith CEL, Natarajan S, Basu B, Best SK, Stevenson T, Trowbridge R, Grellscheid SN, Bond J, Foster R, Johnson CA. bioRxiv. 2020.11.26.393801. 10.1101/2020.11.26.39380

29. Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation.
Vietri M, Schultz SW, Bellanger A, Jones CM, Petersen LI, Raiborg C, Skarpen E, Pedurupillay CRJ, Kjos I, Kip E, Timmer R, Jain A, Collas P, Knorr RL, Grellscheid SN, Kusumaatmaja H, Brech A, Micci F, Stenmark H, Campsteijn C. Nat Cell Biol. 2020 22, 856–867. 10.1038/s41556-020-0537-5

2019

2018

25. Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.
Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari-Jovin S, Dolan D, Droop A, Collin J, Bronstein R, Mehrotra S, Farkas M, Hilgen G, White K, Pan K-T, Treumann A, Hallam D, Bialas K, Chung G, Mellough C, Ding Y, Krasnogor N, Przyborski S, Zwolinski S, Al-Aama J, Alharthi S, Xu Y, Wheway G, Szymanska K, McKibbin M, Inglehearn CF, Elliott DJ, Lindsay S, Ali RR, Steel DH, Armstrong L, Sernagor E, Urlaub H, Pierce E, Lührmann R, -Grellscheid SN, Johnson CA, Lako M. Nat Commun. 2018 9, 4234. 10.1038/s41467-018-06448-y

24. Human iPSC-derived RPE and retinal organoids reveal impaired alternative splicing of genes involved in pre-mRNA splicing in PRPF31 autosomal dominant retinitis pigmentosa.
Lako M, Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari-Jovin S, Dolan D, Droop A, Collin J, Hilgen G, Armstrong L, Sernagor E, Luehrmann R, Grellscheid SN, Johnson C. Invest Ophthalmol Vis Sci. 2018 59(9):1563. 10.1101/232397

23. Medicinal Mascarene Aloes: An audit of their phytotherapeutic potential.
Lobine D, Cummins I, Govinden-Soulange J, Ranghoo-Sanmukhiya M, Lindsey K, Chazot PL, Ambler CA, Grellscheid SN, Sharples G, Lall N, Lambrechts IA, Lavergne C, Howes M-JR. Fitoterapia. 2018 124, 120-126. 10.1016/j.fitote.2017.10.010.

2017

21. Cellular senescence drives age-dependent hepatic steatosis.
Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson C, Lahat A, Day C, Burt A, Palmer A, Anstee Q, Grellscheid SN, Hoeijmakers J, Barnhoorn S, Mann D, Bird T, Vermeij W, Kirkland J, Passos J, Zglinicki T, Jurk D. Nat Commun. 2017 8, 15691. 10.1038/ncomms15691

2016

20. Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.
Feracci M, Foot JN, Grellscheid SN, Danilenko M, Stehle R, Gonchar O, Kang H-S, Dalgliesh C, Meyer NH, Liu Y, Lahat A, Sattler M, Eperon IC, Elliott DJ, Dominguez C. Nat Commun. 2016, 10355. 10.1038/ncomms10355

2015

19. A tale of two paralogs: human Transformer2 proteins with differential RNA-binding affinities.
Ghosh P, Grellscheid SN, Sowdhamini R. JBSD. 2015 34(9), 1979–1986. 10.1080/07391102.2015.1100551

18. Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts.
Holly AC, Grellscheid S, van de Walle P, Dolan D, Pilling LC, Daniels DJ, von Zglinicki T, Ferrucci L, Melzer D, Harries LW. Biogerontology. 2015 16(4):423-34. 10.1007/s10522-015-9560-5

17. Molecular mechanisms of mTOR regulation by stress.
Heberle AM, Prentzell MT, van Eunen K, Bakker BM, Grellscheid SN, Thedieck K. Mol Cell Oncol. 2014 2(2):e970489. 10.4161/23723548.2014.970489

16. TSC1 activates TGF-β-Smad2/3 signaling in growth arrest and epithelial-to-mesenchymal transition.
Thien A, Prentzell MT, Holzwarth B, Kläsener K, Kuper I, Boehlke C, Sonntag AG, Ruf S, Maerz L, Nitschke R, Grellscheid SN, Reth M, Walz G, Baumeister R, Neumann-Haefelin E, Thedieck K. Dev Cell. 2015 32(5):617-30. 10.1016/j.devcel.2015.01.026

2014

15. Detecting translational regulation by change point analysis of ribosome profiling data sets.
Zupanic A, Meplan C, Grellscheid SN, Mathers JC, Kirkwood TB, Hesketh JE, Shanley DP. RNA. 2014 20(10): 1507-1518. 10.1261/rna.045286.114

14. A reassessment of consensus clustering for class discovery.
Yasin Ş, Michailidis G, Li, ZJ. Sci Rep. 2014 4, 6207. 10.1038/srep06207

2013

13. The splicing landscape is globally reprogrammed during male meiosis.
Schmid R, Grellscheid SN, Ehrmann I, Dalgliesh C, Danilenko M, Paronetto MP, Pedrotti P, Grellscheid D, Dixon RJ, Sette C, Eperon IC, Elliott DJ. Nucleic Acids Res. 201341(22), 10170-10184. 10.1093/nar/gkt811

12. Inhibition of mTORC1 by Astrin and stress granules prevents apoptosis in cancer cells.
Thedieck K, Holzwarth B, Prentzell MT, Boehlke C, Kläsener K, Ruf S, Sonntag AG, Maerz L, Grellscheid SN, Kremmer E, Nitschke R, Kuehn EW, Jonker JW, Groen AK, Reth M, Hall MN, Baumeister R. Cell. 2013 154(4): 859-874. 10.1016/j.cell.2013.07.031

2012

11. How does Tra2β protein regulate tissue-specific RNA splicing?
Elliott DJ, Best A, Dalgliesh C, Ehrmann I, Grellscheid SN. Biochem Soc Trans. 2012 40(4): 784–788. 10.1042/BST20120036

2011

10. Identification of evolutionarily conserved exons as regulated targets for the splicing activator tra2β in development.
Grellscheid SN, Dalgliesh C, Storbeck M, Best A, Liu Y, Jakubik M, Mende Y, Ehrmann I, Curk T, Rossbach K, Bourgeois CF, Stevenin J, Grellscheid D, Jackson MS, Wirth B, Elliott DJ. PLOS genet. 2011 7(12), e1002390. 10.1371/journal.pgen.1002390

9. Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome.
Rajan P, Dalgliesh C, Carling PJ, Buist T, Zhang C, Grellscheid SN, Armstrong K, Stockley J, Simillion C, Gaughan L, Kalna G, Zhang MQ, Robson CN, Leung HY, Elliott DJ. PLoS One. 2011 6(12), e29088. 10.1371/journal.pone.0029088

8. Molecular design of a splicing switch responsive to the RNA binding protein Tra2β.
Grellscheid SN, Dalgliesh C, Rozanska A, Grellscheid D, Bourgeois CF, Stévenin J, Elliott DJ. Nucleic Acids Res. 2011 39(18), 8092-8104. 10.1093/nar/gkr495

2008

7. Nonsense-mediated messenger RNA decay of survival motor neuron 1 causes spinal muscular atrophy.
Brichta L, Garbes L, Jedrzejowska M, Grellscheid SN, Holker I, Zimmermann K, Wirth B. Hum genet. 2008 123, 141-153. 10.1007/s00439-007-0455-7

2007

6. Applying genetic programming to the prediction of alternative mRNA splice variants.
Vukusic I, Grellscheid SN, Wiehe T. Genomics. 2007 89 (4), 471-479. 10.1016/j.ygeno.2007.01.001

5. The testis‐specific human protein RBMY recognizes RNA through a novel mode of interaction.
Skrisovska L, Bourgeois CF, Stefl R, Grellscheid SN, Kister L, Wenter P, Elliott DJ, Stevenin J, Allain FHT. EMBO Rep. 2007 8 (4), 372-379. 10.1038/sj.embor.7400910

2006

4. Alternative RNA splicing regulation in the testis.
Elliott DJ, Grellscheid SN. Reproduction. 2006 132(6), 811-819. 10.1530/REP-06-0147

3. An apparent pseudo-exon acts both as an alternative exon that leads to nonsense-mediated decay and as a zero-length exon.
Grellscheid SN, Smith CWJ. MolCell Biol. 2006 26 (6), 2237-2246. 10.1128/MCB.26.6.2237-2246.2006

2. A class of human exons with predicted distant branch points revealed by analysis of AG dinucleotide exclusion zone.
Gooding C, Clark F, Wollerton MC, Grellscheid SN, Groom H, Smith CWJ. Genome Biol. 2006 7, 1-19. 10.1186/gb-2006-7-1-r1

2005

1. Regulation of alternative splicing by PTB and associated factors.
Spellman R, Rideau A, Matlin A, Gooding C, Robinson F, McGlincy N, Grellscheid SN, Southby J, Wollerton M, Smith CWJ. Biochem Soc Trans. 2005 33(3): 457–460. 10.1042/BST0330457

Books

3. Differential mRNA alternative splicing. In: Aransay.
Lahat A, Grellscheid SN. Field Guidelines for Genetic Experimental Designs in High-Throughput Sequencing. Springer. 2016. 10.1007/978-3-319-31350-4_5

2. Ribosome profiling. In: Aransay.
Zupanic A, Grellscheid SN. Field Guidelines for Genetic Experimental Designs in High-Throughput Sequencing. Springer. 2016. 10.1007/978-3-319-31350-4_8

1. Detection of alternative Tra2β regulated splicing. In: Application Guide.
Best A, Grellscheid SN, Elliott DJ. QIAGEN. 2016 12. PDF

PhD thesis

The role of cis-acting sequences in the regulation of α-tropomyosin alternative splicing.
Grellscheid SN. University of Cambridge. 2003. Google scholar